Figure 2

Spatial learning performance. (A) (a, b) Mean path lengths (cm) and latencies (seconds) to locate the target platform during place training, (c) swim speed and (d) mean percentage time in the target quadrant during probe trials after completion of water maze testing, with (e) path lengths and (f) latencies during assessment of spatial task retention in the water maze in mice exposed to 15 days of sleep fragmentation and those maintained in control sleep conditions (n = 18 per group; *P<0.0001). (B) Mice exposed to sleep fragmentation (a, b) showed less immobility during the forced swim test, (c) performed significantly more entries into the closed arms, and (d) spent significantly less time in the open arms of the elevated plus maze compared with mice having control sleep conditions (n = 18/group; * P<0.002).