Table 2 Correlation of CSF cytokine/chemokine levels and CSF parameters
From: CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation
APRIL | BAFF | CXCL12 | CXCL13 | CCL19 | |
|---|---|---|---|---|---|
Cell count | P <0.0001 | P <0.0001 | P <0.0001 | P <0.0001 | P <0.0001 |
r = 0.4350 | r = 0.4967 | r = 0.4954 | r = 0.7583 | r = 0.5461 | |
Qalb | P = 0.0067 | P = 0.0003 | P <0.0001 | P <0.0001 | P <0.0001 |
r = 0.2669 | r = 0.3507 | r = 0.5011 | r = 0.5066 | r = 0.4600 | |
Intrathecal IgG | P = 0.9332 | P = 0.2370 | P = 0.8147 | P = 0.0002 | P = 0.0808 |
r = 0.008406 | r = 0.1175 | r = -0.02337 | r = 0.3540 | r = 0.1737 | |
Intrathecal IgA | P = 0.0305 | P = 0.0034 | P = 0.0060 | P <0.0001 | P = 0.2992 |
r = 0.2143 | r = 0.2863 | r = 0.2692 | r = 0.3965 | r = 0.1038 | |
Intrathecal IgM | P = 0.0018 | P = 0.0330 | P = 0.0540 | P = 0.0002 | P = 0.5006 |
r = 0.3049 | r = 0.2103 | r = 0.1904 | r = 0.3567 | r = 0.06745 | |
OCBs | P = 0.5013 | P = 0.8673 | P = 0.0971 | P = 0.0104 | P = 0.8844 |
r = -0.06767 | r = 0.01684 | r = -0.1660 | r = 0.2539 | r = 0.01465 | |
All B cells | P = 0.4474 | P = 0.0478 | P = 0.0312 | P <0.0001 | P = 0.0855 |
(CD19+) | r = 0.07422 | r = 0.1918 | r = 0.2084 | r = 0.6264 | r = 0.1670 |
B cells | P = 0.8110 | P = 0.0945 | P = 0.0859 | P <0.0001 | P = 0.2317 |
(CD19+D138-) | r = 0.02339 | r = 0.1625 | r = 0.1668 | r = 0.5756 | r = 0.1166 |
Plasmablasts | P = 0.0317 | P = 0.0100 | P = 0.0426 | P <0.0001 | P = 0.0067 |
(CD19+CD138+) | r = 0.2078 | r = 0.2481 | r = 0.1965 | r = 0.5828 | r = 0.2605 |
T cells | P = 0.7699 | P = 0.1733 | P = 0.0036 | P = 0.5173 | P = 0.0337 |
(CD3+) | r = -0.02931 | r = -0.1359 | r = -0.2861 | r = -0.06485 | r = -0.2105 |
Monocytes | P = 0.0050 | P <0.0001 | P = 0.0034 | P <0.0001 | P = 0.0030 |
(CD14+) | r = -0.2706 | r = -0.3866 | r = -0.2819 | r = -0.5834 | r = -0.2861 |