Figure 9
From: Microglia P2Y6 receptors mediate nitric oxide release and astrocyte apoptosis
Schematic representation of the purinergic mechanisms mediating microglia-astrocyte communication in lipopolysaccharide (LPS) cultures. Uracil nucleotides released during inflammatory response activate microglia P2Y6 receptors coupled to the phospholipase C (PLC) - protein kinase C (PKC) pathway, which mediates an increase in inducible nitric oxide synthase (iNOS) expression and consequently, in nitric oxide (NO) release. Diffusible NO mediates astroglial apoptosis.