Figure 2
From: The immune response after hypoxia-ischemia in a mouse model of preterm brain injury
Brain injury after 50-minute hypoxia-ischemia (HI) insult. Dot graphs show the volume difference between the ipsilateral and contralateral hemispheres in gray matter (A) and white matter (B) at 7 days after 50-minute HI in PND 5 mice (n = 16). Abbreviations: Contra: contralateral hemisphere; Ipsi: ipsilateral hemisphere. *P < 0.05 by Student's unpaired t-test. Data are presented as mean ± SEM. (C-H) Representative photomicrographs of thionin/acid fuchsin-stained sections show diffuse injury in the subcortical white matter area (D and G) and focal granular layer loss in the hippocampus CA3 area (D and H) that is only observed in the ipsilateral hemisphere and not in the contralateral hemisphere (C, E, and F) at 3 days after HI in PND 5 mice. Arrows in (D) indicate focal injury in the CA1 granular layer of the hippocampus in the ipsilateral hemisphere.