Skip to main content
Figure 3 | Journal of Neuroinflammation

Figure 3

From: Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood

Figure 3

Postnatal day 14 (PND14) neonatal lipopolysaccharide (LPS) differentially alters anxiety-like behavior, depressive-like behavior and spatial memory at adolescence (PND30) and adulthood (PND90). Anxiety-like behavior was evaluated in the novelty-suppressed feeding test (NSFT) by measuring the latency (sec) of first food consumption in the center of the arena (n = 20). Depressive-like behavior was evaluated in the forced swim test (FST) by measuring the swimming occurrence (number) during 5 min (n = 20). Data are expressed as mean ± SEM. P <0.05. Spatial memory was evaluated in the Y-maze test by measuring the time spent exploring the novel and the familiar arms over a 5-min test and after a 30-min retention delay (n = 20). Data are expressed as mean ± SEM. *P <0.05, ***P <0.001, for familiar arm compared to novel arm.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094