Figure 5

Effect of intrathecally injected mesenchymal stem cells on thermal hypersensitivity after partial sciatic nerve ligation. Sham- (A,B) or partial sciatic nerve ligation (PSNL)- (E,F) operated animals either injected with vehicle (“no cells”) or mesenchymal stem cells (MSCs; “cells”) were tested with the thermal paw stimulator for 20 days after surgery. Paw withdrawal latencies (PWL) of the ipsilateral (A or E) or contralateral (B or F) hindpaws are expressed as percentage of the baseline PWL. (C,D and G,H) Area under the curve (AUC) analysis of the corresponding graphs, analysed by two-tailed student’s t-test; data shown are mean values with SEM. Each group consisted of 9 to 11 animals.