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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Estrogen receptor alpha deficiency protects against development of cognitive impairment in murine lupus

Figure 6

Hippocampal Iba1 staining in MRL/lpr and MRL/lpr ERαKO mice. (A) IHC images demonstrate diffuse glial activation and clustered microglia in the hippocampus of both MRL/lpr and MRL/lpr ERαKO mice. Scale bar in lower right corner represents 100 microns. (B) Higher magnification (20×) images demonstrating increased Iba1 immunopositive cells in MRL/lpr WT versus ERαKO mice. Scale bar in lower right corner represents 50 microns. (C) Counts of Iba1+ cells in CA1 and dentate regions of hippocampus showing a significant reduction in Iba1+ cells in MRL/lpr ERαKO mice (n = six to eight mice per group, average of three random fields each).

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Journal of Neuroinflammation

ISSN: 1742-2094