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Figure 4 | Journal of Neuroinflammation

Figure 4

From: The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism

Figure 4

Levels of pro-inflammatory cytokines in the serum and cortex of mice following systemic lipopolysaccharide (LPS) stimulation. Wild-type (WT) mice (white) or p38αΔLysM-Cre knockout (KO) mice (black) were injected intraperitoneally (IP) with 5 mg/kg LPS. The cytokine response in the serum was significantly reduced in the p38αΔLysM-Cre KO mice (A), while the response in the CNS was increased in the p38αΔLysM-Cre KO mice compared to the WT mice (B) (n =5 to 8 per group) (*P <0.05; **P < 0.01; ***P <0.001).

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Journal of Neuroinflammation

ISSN: 1742-2094