Figure 4

Body weight, motor performance, and survival of R723- or vehicle-treated mSOD1 ^G93A mice. (A) Time course of motor performance in the rotarod test. Performance of R723-treated (open circles, n = 25) and vehicle-treated (filled circles, n = 27) mSOD1^G93A mice were comparable. (B) Changes in mean body weight of R723-treated (n = 25) and vehicle-treated (n = 27) mSOD1 ^G93A mice. (C) Kaplan-Meier survival curve. R723 treatment did not affect the survival of mSOD1 ^G93A mice (R723-treated group, n = 25; vehicle-treated group, n = 28) (P = 0.964). (D) Nissl staining of transverse sections of lumbar spinal cord. Motor neurons were counted and statistical analysis is shown. Scale bar = 50 μm. Data are expressed as means ± SEM. Statistical analysis was performed using ANOVA (A, B), log-rank test (C), and the Mann-Whitney U-test.