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Table 4 IL-1Β production by purified peripheral blood monocytes in the study groups

From: Cytokine profiles by peripheral blood monocytes are associated with changes in behavioral symptoms following immune insults in a subset of ASD subjects: an inflammatory subtype?

Study group Without stimuli [pg/ml] LPS Zymosan CL097
ASD-ISd     
- Flare 736.6 ± 242.4a 2141.2 ± 819.4b 2665.0 ± 569.5b 3062.0 ± 888.2
- Non-flare 424.8 ± 328.2 1596 ± 57.5 1990.4 ± 664.7 2925.8 ± 862.0
ASD/NFA 404.2 ± 242.4 582.7 ± 427.7c 373.7 ± 1620.7c 1056.8 ± 572.6c
ASD/non-NFA 471.9 ± 299.1 1592.8 ± 599.4 566.3 ± 1823.2 2729.2 ± 1025.4
Non-ASD/NFA 639.0 ± 424.0 1557.5 ± 566.6 1826 ± 678.2 2373.6 ± 1220.0
Normal control 361.2 ± 316.8 1580.4 ± 428.5 1709.9 ± 597.2 2668.7 ± 609.1
PANS     
- Flare 797.0 ± 598.8a 2310.9 ± 1057.3 2124.2 ± 590.4 3065.1 ± 683.8
- Non-Flare 731.9 ± 427.0a 1980.8 ± 845.6 1888.1 ± 630.2 2615.6 ± 791.6
  1. aSpontaneous production of IL-1Β is higher in `flare’ ASD-IS cells than in `non-flare’ ASD-IS cells in matched pair analysis as shown in Figure 3. IL-β levels produced spontaneously is also higher than those produced by normal, ASD/NFA, and ASD/non-NFA (P <0.02 for `flare’ ASD-IS cells and P <0.05 for PANS cells).
  2. bIL-1ß levels produced by `flare’ ASD-IS cells in response to LPS and zymosan are higher than those by non-flare ASD-IS cells by matched pair analysis as shown in Figure 4. These levels are also higher than those produced by other control cells except for PANS cells.
  3. cIL-1ß production by ASD/NFA cells in response to LPS, zymosan, and CL097 are lowest among the study groups (P <0.001).
  4. d Abbreviations used; ASD, autism spectrum disorders, ASD-IS; ASD-inflammatory subtype, IL, interleukin; LPS, lipopolysaccharide; NFA, non-IgE mediated food allergy; PANS, pediatric acute-onset neuropsychiatric syndrome.