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Table 6 IL-10 production by purified peripheral blood monocytes in the study groups

From: Cytokine profiles by peripheral blood monocytes are associated with changes in behavioral symptoms following immune insults in a subset of ASD subjects: an inflammatory subtype?

The study group Without stimuli [pg/ml] LPS ratioa Zymosan CL097
ASD-ISc     
- Flare 848.6 ± 344.8 1.48 ± 0.88b 1.15 ± 0.43b 0.55 ± 0.632
- Non-Flare 648.7 ± 382.1 2.64 ± 1.37 2.15 ± 1.09 1.23 ± 1.12
ASD/NFA 812.4 ± 365.5 1.96 ± 0.91 1.55 ± 0.75 0.89 ± 0.72
ASD/non-NFA 855.4 ± 364.7 1.93 ± 1.12 1.63 ± 1.03 0.93 ± 0.91
Non-ASD/NFA 948.5 ± 362.7 1.93 ± 1.38 1.66 ± 1.67 0.67 ± 0.51
Normal control 677.7 ± 290.0 2.40 ± 1.10 1.93 ± 1.06 0.76 ± 0.69
PANS     
- Flare 791.7 ± 449.4 1.87 ± 0.95 1.82 ± 1.27 1.38 ± 0.99
- Non-Flare 945.8 ± 455.4 1.93 ± 1.14 1.66 ± 0.84 1.58 ± 1.07
  1. aIL-10 production in response to LPS, zymosan, and CL097 were expressed as a ratio of IL-10 produced in these stimulants/IL-10 produced in the absence of stimuli. It should be noted that IL-10 production tends to be lower in the presence of CL097 in most of the study groups.
  2. bIL-10 production by `flare’ ASD-IS cells were lower than `non-flare’ ASD-IS cells with matched pair analysis as detailed in Figure IL-10 production by `flare’ ASD-IS cells in response to LPS and zymosan were also lower than ASD/NFA and normal control cells (P <0.01). IL-10 production by `flare’ ASD-IS cells in response to CL097 cells were also lower than those produced by PANS cells (P <0.01).
  3. c Abbreviations used; ASD, autism spectrum disorder; ASD-IS, ASD-inflammatory subtype; IL, interleukin; LPS, lipopolysaccharide; NFA, non-IgE mediated food allergy; PANS, pediatric acute-onset neuropsychiatric syndrome.