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Table 2 Baseline parameter comparisons of low and high groups

From: Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection

  Low group (baseline CSF neopterin <21, n = 33) High group (baseline CSF neopterin >21, n = 11) P value
Age (years) 37 (30 to 46) 36 (28 to 47) 0.87
Days post-transmission 136 (84 to 189) 70 (34 to 191) 0.23
Blood CD4+ T-cells (cells/μL) 601 (444 to 750) 308 (275 to 389) <0.001
Blood CD8+ T-cells (cells/μL) 993 (692 to 1,269) 1,037 (725 to 1,707) 0.58
Plasma HIV RNA (log10 copies/mL) 4.2 (3.8 to 4.8) 5.3 (4.4 to 5.9) 0.02
CSF HIV RNA (log10 copies/mL) 2.5 (1.7 to 3.2) 3.7 (2.8 to 4.9) 0.006
CSF:plasma HIV RNA ratio (log10) −1.8 (−2.2 to −1.2) −1.4 (−2.3 to −0.5) 0.37
CSF WBC count 6 (2.5 to 9.5) 10 (1 to 11) 0.61
Plasma neopterin (nmol/L) 13.9 (10.2 to 18.2) 21.5 (18.3 to 37.5) 0.006
CSF neopterin (nmol/L) 8.5 (5.8 to 11.8) 39.1 (29.2 to 56.6) <0.001
CSF:plasma neopterin ratio 0.66 (0.42 to 0.8) 1.8 (1.3 to 2.6) <0.001
CSF:plasma albumin ratio 5.4 (4.3 to 6.4) 7.4 (4.6 to 10.9) 0.06
  1. Unless otherwise stated values are represented as median (interquartile range). CD, cluster of differentiation; CSF, cerebrospinal fluid; WBC, white blood cell count.