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Figure 5 | Journal of Neuroinflammation

Figure 5

From: CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function

Figure 5

Cerebrovascular contractile responses to 5-CT at 72 h post-SAH. Concentration-response curves were elicited by the cumulative application of 5-CT to (A) MCA and (B) basilar arteries. The 5-CT induced contractile responses show two phases; the first part represents elevation in the 5-HT1B receptor expression and the second part shows unaltered 5-HT2A receptor function in MCA and BA after SAH. The detailed pharmacological characterizations have been previously published [4],[9],[28],[29]. Values are expressed as percentage of the K+-induced contraction and are presented as mean ± SEM. **P <0.01 and ***P <0.001. Number of animals in each group, n = 6–8.

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Journal of Neuroinflammation

ISSN: 1742-2094