Figure 1

Effects of hypoxic-ischemia (HI) or lipopolysaccharide (LPS) alone on brain injury. Mouse pups were exposed to different duration of HI or different doses of LPS on P5, and neuropathological examinations were performed on P17. (A) Compared to the control groups (n = 6), pups exposed to 40 minute-HI (n = 9), but not to 30-minute HI (n = 10), had significant injury in the cortex (upper panel) and decreased myelin basic protein (MBP) expression in the white matter of the ipsilateral hemispheres (middle panel). There were no significant differences in MBP expression in the contralateral white matter among the control, 30-minute HI and 40-minute HI groups (lower panel). (B) Compared to the normal saline (NS) group (n = 5), the 0.05-mg/kg LPS (n = 5) and 0.5-mg/kg LPS (n = 5) groups showed no evident cortical (Nissl staining, upper panel) or white matter injury (MBP staining, middle and lower panels). Scale bar = 200 μm. Values are means ± SEM. **P < 0.01, ***P < 0.001.