Effect of spermine in LPS-induced memory impairment. Post-training administration of spermine (0.3 mg/kg, intraperitoneally) attenuates LPS-induced (250 μg/kg, intraperitoneally) discrimination impairments on novel object recognition task. Data are expressed as mean ± standard error of the mean for 15 animals in each group. *P < 0.005 compared with saline group, #P < 0.005 compared with LPS and saline group (two-way ANOVA followed by the Bonferroni post-hoc test). LPS, lipopolysaccharide; SAL, saline; SPM, spermine.