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Table 1 Genes regulated by C/EBPβ involved in immune/inflammatory response

From: CCAAT/enhancer binding protein β directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor

Upregulated genes in C/EBPβ +/+
Accession no. Symbol Name Biological processes
NM_009778 C3 Complement component 3 Complement activation, immune and inflammatory response, response to stress.
NM_013590 Lzp-s Plysozyme structural Cell wall macromolecule catabolic processes, defence response to bacterium.
NM_016972 S1c7a8 Solute carrier family (cationic amino acid transporter, y + system), member 8 Integral component of membrane, amino acid transmembrane transporter activity, toxin transporter activity.
NM_009662 Alox 5 Arachidonate 5-lipoxygenase Defence response, response to stress, immune response, oxidoreductose and dioxygenase activity.
NM_130452 Bbox1 Butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) Carnitine biosynthesis, adrenal gland development, metabolism.
NM_027961.1 Wfdc3 WAP four-disulfide core domain 3 Inflammation, bacterial opsonization, immune responses.
NM_026331 S1c25a37 Solute carrier family 25, member 37 Mitochondrial biogenesis, neurotransmitter transporter.
NM_053262 Dhrs8 Dehydrogenase/reductase (SDR family) member 8 Steroid dehydrogenase activity, androgen catabolic process, lipid metabolic process, oxidation-reduction process.
Downregulated genes in C/EPBβ +/+
Accession no. Symbol Name Biological process
NM_009628.2 ADNP Activity-dependent neuroprotective protein Neuropeptide signalling pathway, neurological disorders, inflammation.
NM_008596.1 Sypl2 Synaptophysin-like 2 transporter activity, cellular calcium ion homeostasis.
NM_008380 Inhba Inhibin beta-A Cytokine-cytokine receptor interaction, growth factor activity, cell cycle arrest, cellular response to cholesterol.
NM_001002927 Penk1 Preproenkephalin 1 Response to stress, neuropeptide signalling pathway, signal transduction.
NM_172479 S1c38a5 Solute carrier family 38, member 5 Amino acid transport across plasma membrane, oxidative stress, antioxidant defence.
NM_010796 Mg11 Macrophage galactose N-acetyl-galactosamine specific lectin 1 Inflammation, macrophage polarization.
NM_008198 Cfb Complement factor B Response to stress, complement activation, immune response.
NM_026954 Tusc1 Tum or suppressor candidate 1 Chronic inflammation, cell cycle regulation.
NM_145575 Cald1 Caldesmon 1 Immune response.