Table 1 Genes regulated by C/EBPβ involved in immune/inflammatory response
Upregulated genes in C/EBPβ +/+ | |||
|---|---|---|---|
Accession no. | Symbol | Name | Biological processes |
NM_009778 | C3 | Complement component 3 | Complement activation, immune and inflammatory response, response to stress. |
NM_013590 | Lzp-s | Plysozyme structural | Cell wall macromolecule catabolic processes, defence response to bacterium. |
NM_016972 | S1c7a8 | Solute carrier family (cationic amino acid transporter, y + system), member 8 | Integral component of membrane, amino acid transmembrane transporter activity, toxin transporter activity. |
NM_009662 | Alox 5 | Arachidonate 5-lipoxygenase | Defence response, response to stress, immune response, oxidoreductose and dioxygenase activity. |
NM_130452 | Bbox1 | Butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) | Carnitine biosynthesis, adrenal gland development, metabolism. |
NM_027961.1 | Wfdc3 | WAP four-disulfide core domain 3 | Inflammation, bacterial opsonization, immune responses. |
NM_026331 | S1c25a37 | Solute carrier family 25, member 37 | Mitochondrial biogenesis, neurotransmitter transporter. |
NM_053262 | Dhrs8 | Dehydrogenase/reductase (SDR family) member 8 | Steroid dehydrogenase activity, androgen catabolic process, lipid metabolic process, oxidation-reduction process. |
Downregulated genes in C/EPBβ +/+ | |||
Accession no. | Symbol | Name | Biological process |
NM_009628.2 | ADNP | Activity-dependent neuroprotective protein | Neuropeptide signalling pathway, neurological disorders, inflammation. |
NM_008596.1 | Sypl2 | Synaptophysin-like 2 | transporter activity, cellular calcium ion homeostasis. |
NM_008380 | Inhba | Inhibin beta-A | Cytokine-cytokine receptor interaction, growth factor activity, cell cycle arrest, cellular response to cholesterol. |
NM_001002927 | Penk1 | Preproenkephalin 1 | Response to stress, neuropeptide signalling pathway, signal transduction. |
NM_172479 | S1c38a5 | Solute carrier family 38, member 5 | Amino acid transport across plasma membrane, oxidative stress, antioxidant defence. |
NM_010796 | Mg11 | Macrophage galactose N-acetyl-galactosamine specific lectin 1 | Inflammation, macrophage polarization. |
NM_008198 | Cfb | Complement factor B | Response to stress, complement activation, immune response. |
NM_026954 | Tusc1 | Tum or suppressor candidate 1 | Chronic inflammation, cell cycle regulation. |
NM_145575 | Cald1 | Caldesmon 1 | Immune response. |