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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

Figure 2

Scutellarin reduced Notch-1 expression in activated microglia in vivo and in vitro . Confocal images showing the expression of Notch-1 (red) in lectin + microglia (green, arrows) in the penumbral zones of middle cerebral artery occlusion (MCAO) rat (D-F) and following treatment with scutellarin (G-I). An enhanced expression of Notch-1 (E) can be observed in the activated microglia (D) in MCAO rat. A noticeable reduction of Notch-1 expression (H) is observed in activated microglia (G) 7 days following treatment with scutellarin. An upregulation of Notch-1 (N) is observed in lipopolysaccharide (LPS)-activated BV-2 microglia (M) in comparison to control (J-L). Notch-1 is reduced (Q) in activated microglia treated with scutellarin. DAPI - blue. Scale bars in A-R: 50 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094