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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

Figure 6

Protein expression of Notch-1, NICD, RBP-JK and Hes-1 was decreased in MCAO rat and in BV-2 microglia following treatment with scutellarin. (A) The expression levels of Notch-1, Notch intracellular domain (NICD), recombining binding protein suppressor of hairless (RBP-JK) and transcription factor hairy and enhancer of split-1 (Hes-1) in middle cerebral artery occlusion (MCAO) rat brains are depressed significantly at 7 days following treatment with scutellarin (low, SL and high, SH dose) when compared with the MCAO rats not treated with scutellarin. (B) The expression levels of Notch-1, NICD, RBP-JK and Hes-1 in lipopolysaccharide (LPS)-activated BV-2 microglial cells are reduced significantly when given scutellarin treatment. (C) Scutellarin decreases NICD translocation into the nucleus in lipopolysaccharide (LPS)-activated BV-2 microglial cells. Significant differences in protein levels are expressed as * P <0.05 and ** P <0.01. The values represent the mean ± SD in triplicate.

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Journal of Neuroinflammation

ISSN: 1742-2094