PTX3 knockout (KO) mice have increased rotational bias 14 days after middle cerebral artery occlusion (MCAo). No significant difference is observed in infarct size between genotypes 14 days after MCAo, as quantified on cresyl violet-stained coronal brain sections (A). Open field test revealed no difference in parameters reflecting general anxiety and activity such as time mobile, number of line crossings and number of rearings (B). Rotational bias was significant in PTX3 KO but not in wild-type (WT) mice (C) and general motor activity was not affected by the lack of PTX3 (D). Short term memory, measured as the percentage of alternations made on a Y-maze, was not affected (E). Student´s t-test ((A), (B), (C) and (E), n = 4 to 6), one-sample t-test versus 50% ((C), n = 4 to 6) and Mann-Whitney tests ((D), n = 4 to 6) were used. ***P <0.05 were performed. In C, *** corresponds to the result of the one-sample t-test versus 50%. Error bars show SEM ((A), (B), (C) and (E)) or interquartile range (D).