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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

Figure 8

GW0742 prevented the lipopolysaccharide (LPS)-induced increase in the expression levels of proinflammatory mediators in vitro . Microglia were exposed to vehicle or GW0742 for 24 hours after which the cells were exposed 10 ng/ml LPS for 24 hours. The expression levels of IL-6, (A), CCL2 (B), IL-1β (C), iNOS (D) and TNFα (E) were analyzed by qPCR. Results are presented as mean ± SEM. VEH = vehicle- and GW0742 = GW0742-treated mice. **P < 0.01 ***P < 0.001 as analyzed by 1-way ANOVA followed by Tukey’s post hoc test. n = 3 to 4 per group derived from individual experiments and values are normalized to VEH + LPS.

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Journal of Neuroinflammation

ISSN: 1742-2094