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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

Figure 8

β-hydroxybutyric acid (BHBA) inhibits lipopolysaccharide (LPS)-Induced release of pro-inflammatory cytokines via GPR109A in primary rat microglial cells. Attenuation by BHBA (1.5 mM) of LPS-induced release of IL-1β (A), IL-6 (B) and TNF-α (C) from primary rat microglial cells in vitro, this effect is abolished with silencing of GPR109A (A- C) (**P <0.01).

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Journal of Neuroinflammation

ISSN: 1742-2094