Figure 2

DFO ameliorates behavioral performance in LPS-exposed mice. The Morris water maze test was performed as described in the Methods section. (A) Swimming speed during probe testing. (B) Platform-site crossings during probe testing. (C) Percentage of distance travelled in the target quadrant during probe testing. (D) Latency to the platform during spatial working memory testing on days 1, 2, and 3. (E, F) Results of spontaneous locomotor activity showing that neither LPS nor DFO altered the number of line crossings (E) or rears (F) 24 h after LPS administration. (G) Changes of body weight on days 1, 2, and 3. Data are expressed as mean ± SE (n = 25). *P <0.05, **P <0.01, ***P <0.001 vs. control; #P <0.05, ##P <0.01 vs. LPS. Con, control; DFO, deferoxamine; LPS, lipopolysaccharide; SE, standard error.