Figure 6
From: Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology
DHA prevents LPS-induced decrease in mEPSC frequency. A Examples of mEPSC recordings obtained from CA1 pyramidal neurons of sister cultures treated with either control, LPS, DHA or LPS + DHA-containing media. B Graphical representation of the averaged mEPSC IEI (left) and amplitude (right). There is a significant increase in the IEI but no changes in amplitude in the LPS-treated cultures. DHA pre-treatment prevents the decrease in IEI that is caused by LPS. * p < 0.05. C Cumulative distribution of mEPSC IEI (left) and amplitude (right) showing a significant decrease in the IEI in neurons from the LPS-treated cultures that is prevented by DHA.