Blood–brain barrier permeability monitored by magnetic resonance imaging. A. Parametric image K
i map by DCE-MRI represents BBB transfer rate at four weeks after stroke. Color-coded permeability coefficient maps reconstructed from contrast-enhanced MRI data demonstrate the regions of high (red) and low (blue) permeability. B. Histogram demonstrates the quantification of BBB permeability in peri-infarct areas (light blue areas in the brain slice cartoon). *P = 0.0504 versus vehicle group, n = 8 in each group. C. RECA1 (marker of endothelial cells) immunostaining shows increased density of new vessels in the peri-infarct area (arrows), corresponding to the regions where BBB transfer rate and plasma volume were measured.