Figure 1From: The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis Clinical parameters assessed during acute bacterial meningitis. (A) Animals were weighed before intracisternal inoculation with pneumococci and before sacrificing at 42 hpi. Results are presented as percent difference from 0 to 42 hpi. Weight loss was attenuated in animals pre-treated with the MMP inhibitor (RS) compared to control animals (Ctrl). (B) At 27 hpi, a low-clinical score (CS < 4; severe disease) was observed in fewer (P < 0.05) animals treated with RS compared to littermates receiving vehicle. (C) Survival rates of animals treated with RS or vehicle were similar (hpi, hours post infection; CS, clinical score; *P < 0.05, Fisher’s exact test; ***P < 0.001, Student’s t-test).Back to article page