Clinical parameters assessed during acute bacterial meningitis. (A) Animals were weighed before intracisternal inoculation with pneumococci and before sacrificing at 42 hpi. Results are presented as percent difference from 0 to 42 hpi. Weight loss was attenuated in animals pre-treated with the MMP inhibitor (RS) compared to control animals (Ctrl). (B) At 27 hpi, a low-clinical score (CS < 4; severe disease) was observed in fewer (P < 0.05) animals treated with RS compared to littermates receiving vehicle. (C) Survival rates of animals treated with RS or vehicle were similar (hpi, hours post infection; CS, clinical score; *P < 0.05, Fisher’s exact test; ***P < 0.001, Student’s t-test).