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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Calcium dysregulation via L-type voltage-dependent calcium channels and ryanodine receptors underlies memory deficits and synaptic dysfunction during chronic neuroinflammation

Figure 1

Morris water maze spatial memory task performance was assessed beginning in the third week of LPS (25 ng/hr) or aCSF infusion and drug treatment with either vehicle, dantrolene (5 mg/kg), or nimodipine (5 mg/kg) with 12 to 15 rats per infusion × drug group. Performance was assessed by (A) path length and (C) latency to locate the hidden platform across days of training, as well as average swim speed (B) across all trials. Data expressed as mean ± SEM. *Indicates a significant difference from treatment-matched aCSF controls, †indicates a significant difference from LPS + vehicle rats within the LPS infusion group. Significance determined by P < 0.05. LPS lipopolysaccharide, aCSF artificial cerebrospinal fluid.

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Journal of Neuroinflammation

ISSN: 1742-2094