Figure 7
From: Endogenous antibodies contribute to macrophage-mediated demyelination in a mouse model for CMT1B
Antibody reconstitution reverts the ameliorated demyelinating phenotype in P0het JHD−/− mice. (A) Representative ultrathin sections of femoral quadriceps nerves from 6-month-old IgG reconstituted P0wt JHD−/−, P0het JHD+/+ controls, and IgG reconstituted P0het JHD−/− mice. Asterisks indicate abnormally myelinated fibers. Scale bar, 5 μm. (B, C) Quantification of abnormally myelinated fibers (B) and signs of demyelination (onion bulbs) (C) in control and reconstituted mice reveal a significantly aggravated myelin degeneration in IgG reconstituted P0het JHD−/− mutants. Note also a non-significant trend of increased pathological alterations in control-reconstituted animals (+KLH, +IgG Fc). (n = 3 to 5). Kruskal-Wallis test with Bonferroni-Holm correction. *P < 0.05; **P < 0.01.