Skip to main content

Table 3 Average fold change a in chemokine/cytokine expression in the presence of various MAPK pathway inhibitors

From: Inflammatory mediator release from primary rhesus microglia in response to Borrelia burgdorferi results from the activation of several receptors and pathways

Cytokine/treatment (2.5 μM)

IL-6

CXCL8

CCL2

TNF

MEK1/2

2.639

2.215

3.813

31.546

(±0.445)

(±0.226)

(±1.138)

(±18.767)

JNK

1.475

1.760

1.512

3.991

(±0.219)

(±0.202)

(±0.083)

(±0.508)

P38

1.382

1.397

1.153

6.301

(±0.065)

(±0.057)

(±0.142)

(±2.338)

  1. aFold change values were calculated as B. burgdorferi with solvent alone/B. burgdorferi with inhibitor from four experiments for each treatment with microglia from two to three animals. Values higher than 1.0 represent fold-down regulation of chemokine/cytokine while values less than 1.0 represent an increase. Standard error of the mean (SEM) is indicated within parentheses. Values that were significantly downregulated in all of the experiments are indicated in italics. CCL2, chemokine (C-C) motif ligand 2; CXCL8, chemokine (C-X-C) motif ligand 8; IL-6, interleukin 6; JNK, Jun N-terminal kinase; MEK, MAP kinase kinase; TNF, tumor necrosis factor.
Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094