Dose-dependent suppression of IL-1β up-regulation by MW151. Mice were subjected to sham injury or CHI, and injected i.p. at 6 h p.i. with saline vehicle (veh). CHI mice were injected i.p. at 6 h p.i. with MW151 at one of three different doses (1, 5, and 10 mg/kg). Levels of IL-1β (A) and CCL2 (B) protein were measured in cortex homogenates at the 9-h p.i. time point. *P < 0.05, ***P < 0.001 compared to sham mice. ‡P < 0.05, ‡‡P < 0.01 CHI + veh compared to CHI + MW151 (n = 10 sham + veh; n = 20 CHI + veh; n = 9 to 10 CHI + MW151).