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Table 1 Levels of cytokines and chemokines in the cortex at the 9-h p.i. time point

From: Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

Treatment group

IL-1β

IL-6

IL-10

CCL2

CXCL1

sham + veh (n = 7)

4.9 ± 1.3

16.1 ± 10.8

1.3 ± 2.0

53.0 ± 7.6

103.8 ± 100.2

CHI + veh (n = 20)

9.8 ± 4.7

41.0 ± 39.1

7.2 ± 5.8

445.1 ± 240.4

274.0 ± 211.2

CHI + MW151 at 3 h and 6 h (n = 10)

7.0 ± 3.8

22.0 ± 13.7

6.5 ± 3.0

403.3 ± 134.5

235.6 ± 125.9

CHI + MW151 at 3 h (n = 10)

6.8 ± 2.5

21.4 ± 15.4

5.6 ± 4.6

393.5 ± 134.6

214.6 ± 132.1

CHI + MW151 at 6 h (n = 9)

6.8 ± 2.5

23.7 ± 21.7

6.9 ± 4.3

414.2 ± 134.5

246.9 ± 88.3

  1. Data are expressed as pg/ml/mg (mean ± SD). CHI, closed head injury; veh, vehicle.