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Table 1 Levels of cytokines and chemokines in the cortex at the 9-h p.i. time point

From: Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

Treatment group IL-1β IL-6 IL-10 CCL2 CXCL1
sham + veh (n = 7) 4.9 ± 1.3 16.1 ± 10.8 1.3 ± 2.0 53.0 ± 7.6 103.8 ± 100.2
CHI + veh (n = 20) 9.8 ± 4.7 41.0 ± 39.1 7.2 ± 5.8 445.1 ± 240.4 274.0 ± 211.2
CHI + MW151 at 3 h and 6 h (n = 10) 7.0 ± 3.8 22.0 ± 13.7 6.5 ± 3.0 403.3 ± 134.5 235.6 ± 125.9
CHI + MW151 at 3 h (n = 10) 6.8 ± 2.5 21.4 ± 15.4 5.6 ± 4.6 393.5 ± 134.6 214.6 ± 132.1
CHI + MW151 at 6 h (n = 9) 6.8 ± 2.5 23.7 ± 21.7 6.9 ± 4.3 414.2 ± 134.5 246.9 ± 88.3
  1. Data are expressed as pg/ml/mg (mean ± SD). CHI, closed head injury; veh, vehicle.