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Table 2 Effect of CHI and MW151 treatment on IBA1, CD45, and GFAP staining

From: Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic

IHC stain Brain region Sham + veh CHI + veh CHI + MW151
( n= 11) ( n= 14) ( n= 14)
IBA1 Neocortex: focus 0.0 ± 0.2 0.3 ± 0.5 0.2 ± 0.3
Neocortex: all 0.0 ± 0.1 0.1 ± 0.2 0.0 ± 0.2
Hippocampus 0.0 ± 0.2 0 ± 0.2 −0.1 ± 0.1
Corpus callosum 0.0 ± 0.5 0.1 ± 0.5 0.1 ± 0.5
Entorhinal cortex 0.0 ± 0.2 0 ± 0.2 0.0 ± 0.2
CD45 Neocortex: focus 0.0 ± 1.3 7.7 ± 10.4 4.4 ± 5.2
Neocortex: all 0.0 ± 1.2 2.3 ± 3.6 1.4 ± 2.5
Hippocampus 0.0 ± 0.7 0.2 ± 0.9 0.3 ± 1.1
Corpus callosum 0.0 ± 0.6 1.2 ± 1.1 1.3 ± 1.3
Entorhinal cortex 0.0 ± 0.7 0.6 ± 1.0 0.9 ± 1.5
GFAP Neocortex: focus 0.0 ± 0.3 4.6 ± 3.7 3.9 ± 3.1
Neocortex: all 0.0 ± 0.2 1.7 ± 1.4 1.5 ± 1.3
Hippocampus 0.0 ± 0.1 0.0 ± 0.1 0.0 ± 0.1
Corpus callosum 0.0 ± 0.2 0.3 ± 0.3 0.4 ± 0.3
Entorhinal cortex 0.0 ± 0.2 0.4 ± 0.3 0.4 ± 0.3
  1. Data expressed as change from sham + veh baseline (mean ± SD). CHI, closed head injury; IHC, immunohistochemical; GFAP, glial fibrillary acidic protein; veh, vehicle.