Figure 2

Expression of inflammatory genes in piglet cerebral cortex lesion 24 hours after cortical impact. IL-1β, TNF-α, CCL2, CCL3, CCL4, and PTGS2 mRNAs in the lesion core were expressed as mean fold change (±SEM) relative to mRNA abundance in cortical tissues from a similar region in the uninjured contralateral hemisphere. Target mRNAs were normalized to GAPDH mRNA as an endogenous control reference, and differences among the groups were tested with Student’s t test. *Means ± SEM differ P < 0.05 relative to contralateral region (n = 6). CCL2, chemokine ligand 2; CCL3, chemokine ligand 3; CCL4, chemokine ligand 4; IL-1β, interleukin-1β; PTGS2, prostaglandin-endoperoxide synthase 2; TNF-α, tumor necrosis factor-α.