Effect of C/EBPδ deficiency on blood-brain barrier status and survival. Brain/plasma albumin ratio in wild-type (open boxes) and C/EBPδ−/− (gray boxes) 30 h after infection. Data are expressed as median with interquartile ranges and 5% to 95% percentiles. *P < 0.05 compared to wild-type control mice (A). Survival of wild-type (black circle) and C/EBPδ−/− mice (black square) after induction of pneumococcal meningitis (n = 12 mice per group; B).