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Table 2 Sequence and binding affinity of Aβ-derived H-2-Db-restricted candidate epitopes

From: Vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer’s disease

Peptides

Amino acid sequences

BIMAS scorea

Aβ23-31

D

V

G

S

N

K

G

A

I

45

23-31NP

A

S

N

S

N

K

G

A

M

286

Aβ33-41

G

L

M

V

G

G

V

V

I

4

33-41NP

A

S

N

V

N

G

V

V

M

343

NP366

A

S

N

E

N

M

D

A

M

286

  1. Amino acid sequence of nonamer peptides derived from Aβ using the BIMAS prediction algorithm. Aβ peptides were modified (NP peptides) by replacing amino acids at the H-2-Db anchor sites (depicted in italic) by amino acids from a high-binding affinity peptide (influenza virus nucleoprotein NP366)
  2. aEstimated half time of dissociation of H-2-Db/peptide complexes, using BIMAS algorithm
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Journal of Neuroinflammation

ISSN: 1742-2094