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Table 1 Mean cytokine concentration (pg/mL) (±SEM) in the ipsilateral sciatic nerve seven days following CCI

From: Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

Cytokine Sham (n = 5) Combined CCI (n = 14) Pain and disability (n = 5) Pain and transient disability (n = 4) Pain alone (n = 5)
IL-1β 73.4 ± 8.2 >3860 >3860 >3860 >3860
IL-6 19.1 ± 3.4 101.2 ± 16.6* 151.8 ± 33.9** 61.4 ± 13.1 82.5 ± 20.2
IL-10 189.2 ± 36.2 162.4 ± 16.1 135.6 ± 19.4 157.0 ± 26.0 168.7 ± 10.8
IL-17A 55.7 ± 1.6 35.2 ± 2.4*** 37.9 ± 3.4 30.3 ± 5.0** 36.4 ± 4.4*
IL-18 77.8 ± 7.1 71.1 ± 2.6 73.2 ± 6.1 67.6 ± 3.5 71.6 ± 4.1
TNF 19.5 ± 1.2 77.6 ± 12.1* 96.0 ± 26.3 61.2 ± 8.3 72.4 ± 23.4
IFN-γ <5 33.5 ± 3.8 35.9 ± 9.1 34.0 ± 0.6 31.3 ± 5.4
MCP-1 151.2 ± 42.7 440.2 ± 34.1*** 546.8 ± 55.2*** 367.9 ± 45.3 391.5 ± 51.5
  1. Statistically significant differences compared to sham are indicated by *P <0.05, **P <0.01 and ***P <0.001. All significant differences have been corrected for family-wise error rate with the Benjamini-Hochberg procedure, with a false discovery rate of q <0.05