Table 1 Mean cytokine concentration (pg/mL) (±SEM) in the ipsilateral sciatic nerve seven days following CCI
Cytokine | Sham (n = 5) | Combined CCI (n = 14) | Pain and disability (n = 5) | Pain and transient disability (n = 4) | Pain alone (n = 5) |
|---|---|---|---|---|---|
IL-1β | 73.4 ± 8.2 | >3860 | >3860 | >3860 | >3860 |
IL-6 | 19.1 ± 3.4 | 101.2 ± 16.6* | 151.8 ± 33.9** | 61.4 ± 13.1 | 82.5 ± 20.2 |
IL-10 | 189.2 ± 36.2 | 162.4 ± 16.1 | 135.6 ± 19.4 | 157.0 ± 26.0 | 168.7 ± 10.8 |
IL-17A | 55.7 ± 1.6 | 35.2 ± 2.4*** | 37.9 ± 3.4 | 30.3 ± 5.0** | 36.4 ± 4.4* |
IL-18 | 77.8 ± 7.1 | 71.1 ± 2.6 | 73.2 ± 6.1 | 67.6 ± 3.5 | 71.6 ± 4.1 |
TNF | 19.5 ± 1.2 | 77.6 ± 12.1* | 96.0 ± 26.3 | 61.2 ± 8.3 | 72.4 ± 23.4 |
IFN-γ | <5 | 33.5 ± 3.8 | 35.9 ± 9.1 | 34.0 ± 0.6 | 31.3 ± 5.4 |
MCP-1 | 151.2 ± 42.7 | 440.2 ± 34.1*** | 546.8 ± 55.2*** | 367.9 ± 45.3 | 391.5 ± 51.5 |