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Table 3 Mean cytokine concentration (pg/mL) (±SEM) in the L4-L5 spinal cord segment seven days following CCI

From: Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

Cytokine Sham (n = 5) Combined CCI (n = 14) Pain and disability (n = 5) Pain and transient disability (n = 4) Pain alone (n = 5)
IL-1β 88.3 ± 5.8 129.2 ± 5.6*** 143.6 ± 9.3** 116.8 ± 6.4 124.6 ± 10.4
IL-6 58.8 ± 12.1 88.6 ± 4.7* 95.5 ± 7.1 92.3 ± 9.8 78.9 ± 8.3
IL-10 467.6 ± 54.3 559.4 ± 23.8 573.6 ± 19.8 579.1 ± 61.4 529.5 ± 50.3
IL-17A 277.5 ± 33.8 356.8 ± 21.4 409.7 ± 32.9 351.0 ± 22.8 308.6 ± 42.7
IL-18 104.0 ± 11.6 116.2 ± 5.5 112.2 ± 6.4 127.8 ± 14.5 110.9 ± 9.3
TNF 59.8 ± 2.9 66.6 ± 1.9 62.1 ± 1.6 70.2 ± 4.3 66.4 ± 3.7
IFN-γ 60.0 ± 11.2 66.44 ± 6.3 53.4 ± 9.0 65.3 ± 15.3 76.0 ± 9.0
MCP-1 111.7 ± 10.3 135.6 ± 3.5* 138.4 ± 4.5 135.9 ± 6.2 132.6 ± 8.4
  1. Statistically significance differences compared to sham are indicated by *P <0.05, **P <0.01 and ***P <0.001. All significant differences have been corrected for family-wise error rate with the Benjamini-Hochberg procedure, with a false discovery rate of q <0.05