Table 3 Mean cytokine concentration (pg/mL) (±SEM) in the L4-L5 spinal cord segment seven days following CCI
Cytokine | Sham (n = 5) | Combined CCI (n = 14) | Pain and disability (n = 5) | Pain and transient disability (n = 4) | Pain alone (n = 5) |
|---|---|---|---|---|---|
IL-1β | 88.3 ± 5.8 | 129.2 ± 5.6*** | 143.6 ± 9.3** | 116.8 ± 6.4 | 124.6 ± 10.4 |
IL-6 | 58.8 ± 12.1 | 88.6 ± 4.7* | 95.5 ± 7.1 | 92.3 ± 9.8 | 78.9 ± 8.3 |
IL-10 | 467.6 ± 54.3 | 559.4 ± 23.8 | 573.6 ± 19.8 | 579.1 ± 61.4 | 529.5 ± 50.3 |
IL-17A | 277.5 ± 33.8 | 356.8 ± 21.4 | 409.7 ± 32.9 | 351.0 ± 22.8 | 308.6 ± 42.7 |
IL-18 | 104.0 ± 11.6 | 116.2 ± 5.5 | 112.2 ± 6.4 | 127.8 ± 14.5 | 110.9 ± 9.3 |
TNF | 59.8 ± 2.9 | 66.6 ± 1.9 | 62.1 ± 1.6 | 70.2 ± 4.3 | 66.4 ± 3.7 |
IFN-γ | 60.0 ± 11.2 | 66.44 ± 6.3 | 53.4 ± 9.0 | 65.3 ± 15.3 | 76.0 ± 9.0 |
MCP-1 | 111.7 ± 10.3 | 135.6 ± 3.5* | 138.4 ± 4.5 | 135.9 ± 6.2 | 132.6 ± 8.4 |