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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channels expression and impaired tight junction proteins integrity in rat brain

Fig. 8

Immunohistochemical analysis showing the effect of curcumin (100 mg/kg BW) on the expression of claudin 5 in the brain of rats exposed to hypobaric hypoxia at 7620 m for 24 h (a–d). Hypoxia showed poor expression of claudin 5 in the brain of rats under hypoxia. However, it was noticed that curcumin administration resulted in to a significant upregulation of claudin 5 under hypoxia. Curcumin did not modify the claudin 5 levels under normoxia. The figure is representative of at least 4–5 animals from each group (40×). Nor normoxia, Hypo hypoxia, Cur curcumin (100 mg/kg BW)

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Journal of Neuroinflammation

ISSN: 1742-2094