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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Fig. 6

The concentration of QUIN in CSF is inversely correlated with GOSE scores and is significantly more elevated in patients with unfavourable outcome. a Correlative analysis was undertaken using maximal concentration of QUIN in CSF of each patient between day 0 (admission to hospital) and day 5 post-TBI and the GOSE scores assessed at 6 months after TBI. A significant negative correlation (p < 0.05) was observed between QUIN and GOSE scores with r = −0.46 (n = 28). b TBI patients were grouped into favourable (GOSE 5–8, n = 11) and unfavourable outcome (GOSE 1–4, n = 15) and their maximal QUIN concentration compared between the groups. Patients with unfavourable outcome showed a close to significant (p = 0.056) higher concentration of QUIN in CSF compared to patients with favourable outcome

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Journal of Neuroinflammation

ISSN: 1742-2094