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Table 1 Single challenge with lipopolysaccharide (LPS) in mice and rats

From: Systemic inflammation and microglial activation: systematic review of animal experiments

Study Genetic background N Age/weight Sex Type of LPS Site of LPS Dose (mg/kg) Time of termination Microglial activation
Mice          
Henry [33] BALB/c 6 3 m M E. coli (O127:B8) ip 0.33 1 day Yes
Henry [21] BALB/c 7 3–4 m M E. coli (O127:B8) ip 0.33 4 h Yes
    18–20 m      4 h Yes
Carnavale [58] C57BL/6 4 12–15 w M S. equine abortus ip 0.5 1 day Yes
         5 weeks No
Terrando [22] C57BL/6 4 12–14 w M E. coli (O111:B4) ip 1 1 day Yes
         3 days Yes
         1 week No
Chung [36] ICR 7 6 w M U ip 1 6 h Yes
         12 h Yes
         1 day Yes
Chen [25] C57BL/6 4 8–12 w M E. coli (O55:B5) ip 1 1 day No
Laflamme [3] CD1 U 20–25 gr M E. coli (O55:B5) ip 1 U Yes
Gao [59] B6C3F1/J U 7 m M E. coli (O111:B4) ip 1 1 day Yes
         5 months No
Okuyama [41] ICR 10 6 w M S. typhimurium ip 1 3 days Yes
Kaushik [60] BALB/c U 6–8 w U S. enterica ip 5 1 day Yes
Hwang [61] C57BL/6 U 11 w M E. coli (O55:B5) ip 5 3 days Yes
Qin [7] B6:129SF2 U 8 w M E. coli (O111:B4) ip 5 2 h Yes
  C57BL/6 U       3 h Yes
Sierra [6] p7.2fms-EGFP U 2 m B S. typhimurium ip 5 1 day Yes
Masocha [62] C57BL/6 8 8–12 w U E. coli (O111:B4) ip 5 4 h No
         1 day Yes
         1 year Yes
Ha [63] C57BL/6 5 7 w M U ip 5 3 h Yes
O’Callaghan [40] C57BL/6 4 8–10 w M E. coli (O111:B4) ip 5 1 day Yes
         3 months Moderate
Bhaskar [23] C57BL/6 U 2 m U U ip 1 1 day Moderate
        10 1 day Yes
Nishioku [45] ICR 4 8 w M E. coli (O55:B5) ip 20 1 h No
         3 h No
         6 h Yes
         1 day Yes
Smithason [20] C57BL/6 6 10–12 w M U ip 200 2 days Moderate
Sehgal [8] C57BL/6 15 2–3 m M E. coli (O55:B5) sc 3 12 h Yes
Rats          
Monje [64] Fisher 344 3 160–180 gr F U ip 1 1 week Yes
Fan [39] Sprangue-Dawley 6 5 d B E. coli (O55:B5) ip 2 1 day Yes
Wang [65] Sprangue-Dawley 3 280–300 gr M E. coli (O55:B5) ip 5 1 day Yes
Semmler [66] Wistar 4 250–300 gr M E. coli (O127:B8) ip 10 4 h No
         8 h No
         1 day Moderate
Semmler [5] Wistar 5 250–300 gr M E. coli (O127:B8) ip 10 1 day Yes
Garcia-Bueno [67] Sprangue-Dawley 5 260–340 gr M E. coli (O55:B5) iv 0.002 1–3 h Moderate*
Jiang-Shieh [28] Wistar 10 200–250 gr M E. coli (O55:B5) iv 0.05 2 days Yes
Buttini [44] Sprangue-Dawley 2 180–200 gr M E. coli (O55:B5) iv 1 1 day No*
        2.5 and 5 1 h No*
         3 h Moderate*
         6 h Moderate*
         8 h Yes*
         1 day Yes*
         3 day Moderate*
         1 week No*
  1. Column time of termination is the time from the (first) LPS challenge
  2. Abbreviations: N number of animals per group, m months, wk weeks, d days, gr gram, U unknown, M male, F female, B both sexes, ip intraperitoneal, sc subcutaneous, iv intravenous, iv intravenous
  3. *Did not express data in statistical values, no statistical information