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Table 1 Single challenge with lipopolysaccharide (LPS) in mice and rats

From: Systemic inflammation and microglial activation: systematic review of animal experiments

Study

Genetic background

N

Age/weight

Sex

Type of LPS

Site of LPS

Dose (mg/kg)

Time of termination

Microglial activation

Mice

         

Henry [33]

BALB/c

6

3 m

M

E. coli (O127:B8)

ip

0.33

1 day

Yes

Henry [21]

BALB/c

7

3–4 m

M

E. coli (O127:B8)

ip

0.33

4 h

Yes

   

18–20 m

    

4 h

Yes

Carnavale [58]

C57BL/6

4

12–15 w

M

S. equine abortus

ip

0.5

1 day

Yes

        

5 weeks

No

Terrando [22]

C57BL/6

4

12–14 w

M

E. coli (O111:B4)

ip

1

1 day

Yes

        

3 days

Yes

        

1 week

No

Chung [36]

ICR

7

6 w

M

U

ip

1

6 h

Yes

        

12 h

Yes

        

1 day

Yes

Chen [25]

C57BL/6

4

8–12 w

M

E. coli (O55:B5)

ip

1

1 day

No

Laflamme [3]

CD1

U

20–25 gr

M

E. coli (O55:B5)

ip

1

U

Yes

Gao [59]

B6C3F1/J

U

7 m

M

E. coli (O111:B4)

ip

1

1 day

Yes

        

5 months

No

Okuyama [41]

ICR

10

6 w

M

S. typhimurium

ip

1

3 days

Yes

Kaushik [60]

BALB/c

U

6–8 w

U

S. enterica

ip

5

1 day

Yes

Hwang [61]

C57BL/6

U

11 w

M

E. coli (O55:B5)

ip

5

3 days

Yes

Qin [7]

B6:129SF2

U

8 w

M

E. coli (O111:B4)

ip

5

2 h

Yes

 

C57BL/6

U

     

3 h

Yes

Sierra [6]

p7.2fms-EGFP

U

2 m

B

S. typhimurium

ip

5

1 day

Yes

Masocha [62]

C57BL/6

8

8–12 w

U

E. coli (O111:B4)

ip

5

4 h

No

        

1 day

Yes

        

1 year

Yes

Ha [63]

C57BL/6

5

7 w

M

U

ip

5

3 h

Yes

O’Callaghan [40]

C57BL/6

4

8–10 w

M

E. coli (O111:B4)

ip

5

1 day

Yes

        

3 months

Moderate

Bhaskar [23]

C57BL/6

U

2 m

U

U

ip

1

1 day

Moderate

       

10

1 day

Yes

Nishioku [45]

ICR

4

8 w

M

E. coli (O55:B5)

ip

20

1 h

No

        

3 h

No

        

6 h

Yes

        

1 day

Yes

Smithason [20]

C57BL/6

6

10–12 w

M

U

ip

200

2 days

Moderate

Sehgal [8]

C57BL/6

15

2–3 m

M

E. coli (O55:B5)

sc

3

12 h

Yes

Rats

         

Monje [64]

Fisher 344

3

160–180 gr

F

U

ip

1

1 week

Yes

Fan [39]

Sprangue-Dawley

6

5 d

B

E. coli (O55:B5)

ip

2

1 day

Yes

Wang [65]

Sprangue-Dawley

3

280–300 gr

M

E. coli (O55:B5)

ip

5

1 day

Yes

Semmler [66]

Wistar

4

250–300 gr

M

E. coli (O127:B8)

ip

10

4 h

No

        

8 h

No

        

1 day

Moderate

Semmler [5]

Wistar

5

250–300 gr

M

E. coli (O127:B8)

ip

10

1 day

Yes

Garcia-Bueno [67]

Sprangue-Dawley

5

260–340 gr

M

E. coli (O55:B5)

iv

0.002

1–3 h

Moderate*

Jiang-Shieh [28]

Wistar

10

200–250 gr

M

E. coli (O55:B5)

iv

0.05

2 days

Yes

Buttini [44]

Sprangue-Dawley

2

180–200 gr

M

E. coli (O55:B5)

iv

1

1 day

No*

       

2.5 and 5

1 h

No*

        

3 h

Moderate*

        

6 h

Moderate*

        

8 h

Yes*

        

1 day

Yes*

        

3 day

Moderate*

        

1 week

No*

  1. Column time of termination is the time from the (first) LPS challenge
  2. Abbreviations: N number of animals per group, m months, wk weeks, d days, gr gram, U unknown, M male, F female, B both sexes, ip intraperitoneal, sc subcutaneous, iv intravenous, iv intravenous
  3. *Did not express data in statistical values, no statistical information