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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: 1,25-Dihydroxyvitamin D3 attenuates endotoxin-induced production of inflammatory mediators by inhibiting MAPK activation in primary cortical neuron-glia cultures

Fig. 5

Effect of 1,25(OH)2D3 on lipopolysaccharide (LPS)-induced interleukin (IL)-6 and macrophage inflammatory protein (MIP)-2 release. Cultured cells were untreated (PBS) or treated with 1,25(OH)2D3 (100 nM), LPS (100 ng/ml), or 1,25(OH)2D3 plus LPS for 24 h, and then the culture medium was collected to analyze levels of IL-6 and MIP-2. Data are expressed as the mean ± SEM (n = 4 in each group). ***p < 0.001 vs. the control (Cont.); ++ p < 0.01, +++ p < 0.001 vs. LPS

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Journal of Neuroinflammation

ISSN: 1742-2094