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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis

Fig. 3

BDNF induced NR1 phosphorylation in the spinal cord which was reduced by K252a. Western blot (a) showed that incubation of the acutely cultured spinal cord slices with BDNF (50 ng/mL) elicited an increase in the phosphorylation level of NR1 at Ser896 (b). Pre-treatment of the spinal cord slices with a TrkB inhibitor K252a reduced BDNF-elicited NR1 phosphorylation (c). *p < 0.05 vs. control or DMSO alone; #p < 0.05 vs. BDNF (+DMSO)

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Journal of Neuroinflammation

ISSN: 1742-2094