Fig. 3
From: Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes
![Fig. 3](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12974-015-0374-9/MediaObjects/12974_2015_374_Fig3_HTML.gif)
Methamphetamine induces NF-κB p65 transcription factor activation. a Effect of methamphetamine on translocation of NF-κB p65 into the nucleus in C6 cells. b Effect of methamphetamine on phosphorylation of NF-κB p65 in C6 cells. c Pretreatment of C6 cells with the σ-1R antagonist (BD1047; 10 μM), the Src inhibitor (PP2; 10 μM), or the ERK inhibitor (U0126; 10 μM) significantly inhibited methamphetamine-mediated translocation of NF-κB p65 into the nucleus. Representative immunoblots and the densitometric analysis of NF-κB p65/Histone H3 from three separate experiments are presented. All the data are presented as the mean ± SD of three individual experiments. *p < 0.05 and **p < 0.01 compared with control group; #p < 0.05 compared with methamphetamine-treated group