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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes

Fig. 3

Methamphetamine induces NF-κB p65 transcription factor activation. a Effect of methamphetamine on translocation of NF-κB p65 into the nucleus in C6 cells. b Effect of methamphetamine on phosphorylation of NF-κB p65 in C6 cells. c Pretreatment of C6 cells with the σ-1R antagonist (BD1047; 10 μM), the Src inhibitor (PP2; 10 μM), or the ERK inhibitor (U0126; 10 μM) significantly inhibited methamphetamine-mediated translocation of NF-κB p65 into the nucleus. Representative immunoblots and the densitometric analysis of NF-κB p65/Histone H3 from three separate experiments are presented. All the data are presented as the mean ± SD of three individual experiments. *p < 0.05 and **p < 0.01 compared with control group; #p < 0.05 compared with methamphetamine-treated group

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