Fig. 5

MNC proliferation against MOG antigens. a MNC were isolated at 2-week interval from venous blood and tested for proliferation against a panel of 23-mer overlapping MOG peptides. The positive proliferation data from individual monkeys, i.e. against MOG14-36, 24–46 and 34–56, are shown. b At necropsy, MNC were prepared from blood (PBMC), spleen, axillary (ALN), inguinal (ILN), lumbar (LLN) and cervical (CLN) lymph nodes and were tested for their proliferation against MOG peptides and rhMOG. Data of the six monkeys are presented as mean ± SEM. Data are expressed as stimulation index (SI) relative to unstimulated cell cultures. SI values ≥2.0 (dotted line) are considered positive. PSD post-sensitization day