Fig. 8

Clinical response to immunization with linked or unlinked epitopes in IFA. One sibling of each twin was immunized on days 0 and 28 with peptide MOG20-50 (left column); the other sibling was immunized on the same days with a mixture of MOG14-36 and MOG34-56 (right column). All monkeys not displaying EAE symptoms were immunized on days 56 and 84 with the encephalitogenic peptide MOG34-56. All immunizations were with peptides emulsified in IFA. Clinical scores are depicted on the left y-axis (solid line) and the percentage body weight loss compared with day 0 on the right y-axis (dotted line)