Fig. 3
From: Role of glial 14-3-3 gamma protein in autoimmune demyelination
Enhanced tissue damage in 14-3-3 γ-deficient mice suffering from chronic EAE. Representative images of spinal cord cross sections on day 56 p.i. of MOG-EAE are shown. Bar represents 200 μm for all sections. Left side (a, c, e, g) depicts sections from wild-type, right side (b, d, f, h) depicts sections from 14-3-3 γ knockout mice. Arrows mark lesions in b and g, h, or labelled profiles in c–f. a, b CNPase staining reveals enhanced demyelination in 14-3-3 γ −/− mice. c, d GFAP staining reveals enhanced astrocyte activation and gliosis in 14-3-3 γ −/− mice. e, f NogoA staining reveals reduced numbers of oligodendrocyte around a lesion in 14-3-3 γ −/− mice. g, h Silver impregnation reveals reduced axonal densities in lesions of 14-3-3 γ −/− mice