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Table 1 Blinded quantification of parameters of tissue damage on the spinal cord cross sections after induction of MOG 35-55 (n = 6 vs. eight mice per group)

From: Role of glial 14-3-3 gamma protein in autoimmune demyelination

 

Control

14-3-3 γ k.o

p

GFAP pos. cells/mm2 ± SEM

371.8 ± 52.1

595.5 ± 37.0

0.0014

Demyelination of white matter in % ± SEM

3.5 ± 0.55

6.3 ± 0.80

0.037

NeuN pos. cells/mm2 ± SEM

290.0 ± 25.2

228.0 ± 16.7

n.s.

NogoA pos. cells/mm2 ± SEM

117.2 ± 13.2

72.1 ± 8.5

0.028

Axonal density ± SEM

9.1 ± 0.7

7.1 ± 0.6

0.037

  1. All analyses were done on day 56 p.i. Data are given as mean ± SEM
  2. n.s. not significant
  3. *p < 0.05; **p < 0.01
  4. k.o = knockout