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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation

Fig. 6

IL-17A Abs inhibit COX-2, iNOS, BACE1, and APP expression and increase the expression of PSD95 in the aged rats treated with LPS. a The expression of COX-2, iNOS, BACE1, APP, and PSD95 was detected by Western blotting using specific antibodies in the hippocampus of rats. Each blot is representative of three experiments. b Levels of COX-2, iNOS, BACE1, APP, and PSD95 were quantified and normalized to GAPDH levels. Each value was then expressed relative to the control, which was set to 1. The data are presented as the mean ± s.e.m. **P < 0.01 versus control group, ## P < 0.01 versus LPS treatment group

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Journal of Neuroinflammation

ISSN: 1742-2094