Fig. 1
From: NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats
TNF-α and IL-1β protein expression in the CNS as measure by ELISA assay. Asterisks indicate significant differences between the groups. a Aged rats fed with NT-020-supplemented diet show a 20 % reduction of TNF-α protein expression in the hippocampus in comparison with aged rat fed with control diet. b In aged rat fed with NT-020 diet, the IL1-β protein expression in the hippocampus decreased approximately 25 % in comparison with aged rat fed with control diet. There is an overall age-related increase of TNF-α and IL-1β expression in the hippocampus with age. (Two-way analysis of variance (ANOVA) in Fig. 2a, F = 19.91, degrees of freedom (df) = 1, followed by Bonferonni post hoc values (***) p < 0.001. In Fig. 2b, F = 24.09, df = 1, followed by Bonferonni post hoc values (*) p < 0.05. In Fig. 2c, F = 5.045, df = 1, followed by Bonferonni post hoc values (*) p < 0.05)