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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice

Fig. 5

The levels of PV, 4-HNE, and gp91phox in the PFC and hippocampus. a, b Sepsis induced significant decreases in the PV level from day 3 to day 14 and significant increases in the 4-HNE level from 24 h to day 3 in the hippocampus. cf The PV level was decreased and the gp91phox level was increased in the hippocampus at day 14 but not at day 30 in the CLP + vehicle group compared with the sham groups, whereas apocynin treatment reversed these abnormities. There was no significant difference in the PV and gp91phox levels in the PFC among the four groups. Data are presented as mean ± SEM (n = 6). # p < 0.05 vs the sham groups; *p < 0.05 vs the CLP + vehicle group

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