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Table 2 Values of parameters in the different groups of patients with liver disease and in controls

From: The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

Parameter Controls Patients without MHE (p vs. control) Patients with MHE (p vs. control) p values (without MHE vs. with MHE) Global ANOVA
p values
PHES −0.2 ± 0.8a −0.4 ± 0.8 −6 ± 2 <0.001 <0.0001
p < 0.001
Nitrates + Nitrites (μM) 18 ± 3 24 ± 8 29 ± 8 ns <0.0001
p < 0.05 p < 0.001
cGMP in Plasma (pmoles/ml) 4 ± 1 7 ± 3 10 ± 4 <0.05 <0.0001
p < 0.05 p < 0.001
Lymphocyte basal cGMP (pmol/mg prot) 0.169 ± 0.06 0.078 ± 0.06 0.047 ± 0.02 ns <0.0001
p < 0.001 p < 0.01
SNAP-induced cGMP increase (fold) 11 ± 3 21 ± 9 22 ± 11 ns 0.0004
p < 0.01 p < 0.01
ANP (ng/ml) 0.014 ± 0.003 0.015 ± 0.002 0.015 ± 0.002 ns ns
IL-6 (pg/ml) 1 ± 0.6 2.5 ± 1.5 4.7 ± 2.1 <0.001 <0.0001
p < 0.05 p < 0.001
IL-18 (pg/ml) 174 ± 80 281 ± 138 388 ± 138 <0.05 <0.0001
p < 0.05 p < 0.001
Creatinine (mg/dl) 0.74 ± 0.12 0.77 ± 0.19 0.86 ± 0.45 ns ns
Total bilirubin (mg/dl) 0.61 ± 0.16 1.42 ± 0.94 1.05 ± 0.83 ns 0.005
p = 0.003
Albumin (g/dl) 4.49 ± 0.14 3.90 ± 0.56 3.70 ± 0.59 ns <0.001
p = 0.001 p < 0.001
INR 1.06 ± 0.05 1.22 ± 0.36 1.18 ± 0.17 ns 0.08
Ammonia (μM) 72 ± 22 127 ± 40 131 ± 35 ns <0.001
p < 0.001 p < 0.001
  1. Differences between groups were assessed with ANOVA plus post hoc Tukey test
  2. MHE minimal hepatic encephalopathy, PHES Psychometric Hepatic Encephalopathy Score, ANP atrial natriuretic peptide, IL-6 interleukin-6, IL-18 interleukin-18
  3. aValues are expressed as the mean ± SD